Wdr45 Gene Summary [Rat]
Predicted to enable phosphatidylinositol phosphate binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including autophagy of mitochondrion; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr45 |
| Official Name | WD repeat domain 45 [Source:RGD Symbol;Acc:1359718] |
| Ensembl ID | ENSRNOG00000009749 |
| Bio databases IDs | |
| Aliases | WD repeat domain 45 |
| Synonyms | DXImx38e, JM5, NBIA4, NBIA5, Sfc19, WD repeat domain 45, WDRX1, WIPI-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- WD40
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration with brain iron accumulation type 5
- mental retardation
- hereditary disorder
- global developmental delay
- x-linked optic atrophy
- developmental disorder
- X-linked complex neurodevelopmental disorder
- X-linked cerebral-cerebellar-coloboma syndrome
- epilepsy
role in cell
- autophagy by
- assembly
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- autophagy
- protein lipidation
- peroxisome degradation
- positive regulation of autophagic vacuole assembly
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- cytosol
- extrinsic to membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding