Atg2a Gene Summary [Rat]
Predicted to enable lipid transfer activity; phosphatidylinositol-3-phosphate binding activity; and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in organelle membrane contact site; phagophore; and phagophore assembly site. Orthologous to human ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg2a |
| Official Name | autophagy related 2A [Source:RGD Symbol;Acc:1589890] |
| Ensembl ID | ENSRNOG00000060707 |
| Bio databases IDs | |
| Aliases | autophagy related 2A |
| Synonyms | 1810013C15Rik, A830054M12, autophagy related 2A, BLTP4A, LOC684857, mKIAA0404 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atg2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- N-terminal region of Chorein or VPS13
- protein binding
- Autophagy-related protein C terminal domain
- transporter
Pathways
Biological processes and signaling networks where the Atg2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
role in cell
- number
- formation
- formation in
- apoptosis
- migration
- proliferation
- accumulation
- assembly
- autophagy by
- closure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane surface
- lipid droplets
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atg2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- peroxisome degradation
- positive regulation of autophagic vacuole assembly
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- organelle membrane contact site
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- phosphatidylinositol-3-phosphate binding