Cldn10 Gene Summary [Rat]
Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; paracellular transport; and regulation of monoatomic ion transport. Predicted to be located in endoplasmic reticulum and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN10 (claudin 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn10 |
| Official Name | claudin 10 [Source:RGD Symbol;Acc:1308027] |
| Ensembl ID | ENSRNOG00000010085 |
| Bio databases IDs | |
| Aliases | claudin 10 |
| Synonyms | 6720456I16Rik, claudin 10, CLD10, Cldn10a, Cldn10b, CPETRL3, D14Ertd728e, HELIX, OSP-L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the Cldn10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HELIX syndrome
- metastasis
- organismal death
- endometriosis
- gout
- renal clear cell adenocarcinoma
- renal clear cell cancer
- urolithiasis
- thyroid carcinoma
role in cell
- expression in
- apoptosis
- growth
- transmembrane potential
- migration
- invasion by
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- intercellular junctions
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- ion transport
- tight junction assembly
- cell adhesion
- regulation of ion transport
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity