Efnb3 Gene Summary [Rat]
Predicted to enable ephrin receptor binding activity. Involved in positive regulation of presynapse assembly and positive regulation of synaptic transmission. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efnb3 |
| Official Name | ephrin B3 [Source:RGD Symbol;Acc:2541] |
| Ensembl ID | ENSRNOG00000010320 |
| Bio databases IDs | |
| Aliases | ephrin B3 |
| Synonyms | EFL-6, ELF-3, ELK-L3, EPHRIN B3, Epl8, EPLG8, LERK-8, NLERK-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Efnb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- extracellular domain
- transmembrane-ephrin receptor
- Ephrin
- Cupredoxin superfamily
- ephrin receptor binding
- protein binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Efnb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- glioblastoma cancer
- doxorubicin induced cardiotoxicity
- glioblastoma
- gait disturbance
role in cell
- expression in
- proliferation
- formation
- migration
- growth
- collapse
- axonogenesis
- outgrowth
- innervation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Efnb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- adult walking behavior
- negative regulation of axonogenesis
- T cell costimulation
- positive regulation of synaptic transmission
- ephrin receptor signaling pathway
- cell-cell signaling
- nervous system development
- axon choice point recognition
- axon guidance
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- viral receptor activity
- transmembrane-ephrin receptor activity