Cel Gene Summary [Rat]
Enables carboxylic ester hydrolase activity and glycosphingolipid binding activity. Predicted to be involved in ceramide catabolic process; intestinal cholesterol absorption; and pancreatic juice secretion. Located in extracellular space and zymogen granule. Part of protein-containing complex. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cel |
| Official Name | carboxyl ester lipase [Source:RGD Symbol;Acc:2331] |
| Ensembl ID | ENSRNOG00000010406 |
| Bio databases IDs | |
| Aliases | carboxyl ester lipase |
| Synonyms | 1810036E18RIK, BAL, Bile Salt-Stimulated Lipase, BSDL, BSSL, carboxyl ester lipase, CEase, CELL, CEL (MODY8), FAP, FAPP, LIPA, LOC100508206, MODY8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cel often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Carboxylesterase family
- sphingolipid binding
- lipid binding
- lysophospholipase
- sterol esterase
- alpha/beta hydrolases
- MAPK-interacting and spindle-stabilising protein-like
- enzyme
- protein binding
- Proline-rich protein
- Mediator complex subunit 25 synapsin 1
- triacylglycerol lipase
- Mucin-like
- binding protein
- hydrolase
- retinyl-palmitate esterase
Pathways
Biological processes and signaling networks where the Cel gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- Maturity onset diabetes of the young type 8
- insulin resistance
- maturity-onset diabetes of the young
- lipomatosis
- benign neoplasia
- diabetes mellitus
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- exocrine pancreatic dysfunction
role in cell
- cell death
- expression in
- proliferation
- activation in
- cell viability
- replication in
- re-esterification in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- raft fractions
- Cytoplasm
- Golgi region
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- zymogen granules
- multivesicular bodies
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cel gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- retinol metabolic process
- intestinal cholesterol absorption
- pancreatic juice secretion
- ceramide catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- catalytic activity
- retinyl-palmitate esterase activity
- acetylesterase activity
- triglyceride lipase activity
- heparin binding
- sterol esterase activity
- hydrolase activity