Pde4b Gene Summary [Rat]
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in T cell receptor signaling pathway; cAMP-mediated signaling; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde4b |
| Official Name | phosphodiesterase 4B [Source:RGD Symbol;Acc:3280] |
| Ensembl ID | ENSRNOG00000005905 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 4B |
| Synonyms | DPDE4, dunce, Pde4b1, Pde4b2, Pde4B3, Pde4B4, Pde4b5, Pde4b v1, Pde4b v2, Pde4b v3, Pde4b v4, PDE4/IVb, PDEIVB, phosphodiesterase 4B, Phosphodiesterase 4B, cAMP specific |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- catalytic domain
- cAMP-specific phosphodiesterase
- upstream conserved regions 2
- enzyme
- protein binding
- calcium channel regulator
- 3',5'-cyclic-nucleotide phosphodiesterase
- Metal dependent phosphohydrolases with conserved 'HD' motif
- gamma-tubulin binding
- 3',5'-cAMP binding
- upstream conserved region
- ion channel binding
- HDc
- Phosphodiesterase 4 upstream conserved regions (UCR)
Pathways
Biological processes and signaling networks where the Pde4b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preterm birth
- ST-elevation myocardial infarction
- transient ischemic attack
- myocardial ischemia
- infection
- migraines
- coronary disease
- diabetes mellitus
- stroke
- acute kidney injury
role in cell
- phosphorylation in
- expression in
- quantity
- apoptosis
- accumulation in
- migration
- response
- homeostasis
- recruitment
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- centrosome
- cytosol
- dendritic spines
- synaptic vesicles
- Z line
- membrane rafts
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell contraction
- cAMP catabolic process
- neutrophil homeostasis
- cellular response to lipopolysaccharide
- cellular response to epinephrine stimulus
- positive regulation of interferon-gamma production
- neutrophil chemotaxis
- leukocyte migration
- cellular response to xenobiotic stimulus
- T cell receptor signaling pathway
- cAMP-mediated signaling
- positive regulation of interleukin-2 production
- negative regulation of adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- postsynaptic density
- centrosome
- perinuclear region of cytoplasm
- synaptic vesicle
- excitatory synapse
- dendritic spine
- voltage-gated calcium channel complex
- cytosol
- gamma-tubulin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- cAMP binding
- gamma-tubulin binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- calcium channel regulator activity
- ion channel binding
- 3',5'-cyclic-AMP phosphodiesterase activity