Mgat5 Gene Summary [Rat]
Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; manganese ion binding activity; and protein phosphatase inhibitor activity. Predicted to be involved in positive regulation of cell migration; positive regulation of receptor signaling pathway via STAT; and protein N-linked glycosylation via asparagine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Used to study proteinuria. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat5 |
| Official Name | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [Source:RGD Symbol;Acc:620100] |
| Ensembl ID | ENSRNOG00000003614 |
| Bio databases IDs | |
| Aliases | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase |
| Synonyms | 4930471A21RIK, 5330407H02Rik, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, GlcNAc-TV, GNT-V, GNT-VA, LOC100909582, LOC108348294, LOC151162, LOC679424, mannoside acetylglucosaminyltransferase 5, MGAT5A, α-1,6-mannosylglycoprotein 6-β-N-acetylglucosaminyltransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mgat5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
- Glycosyltransferase family 18
- acetylglucosaminyltransferase
- Domain of unknown function (DUF4525)
- enzyme
- manganese ion binding
- glycosyltransferase
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- breast cancer
- epithelial neoplasia
- multiple sclerosis
- chronic lymphocytic leukemia
- dextran sodium sulfate-induced colitis
- adenoma formation
- benign neoplasia
- experimental autoimmune encephalomyelitis
role in cell
- cell viability
- expression in
- proliferation
- binding in
- growth
- invasion by
- production in
- migration
- formation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mgat5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- manganese ion binding
- alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity