Dlc1 Gene Summary [Rat]
Enables enzyme activator activity; phospholipase binding activity; and vinculin binding activity. Involved in cellular response to insulin stimulus. Located in actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlc1 |
| Official Name | DLC1 Rho GTPase activating protein [Source:RGD Symbol;Acc:68416] |
| Ensembl ID | ENSRNOG00000010780 |
| Bio databases IDs | |
| Aliases | DLC1 Rho GTPase activating protein |
| Synonyms | A730069N07RIK, ARHGAP7, deleted in liver cancer 1, DLC1 Rho GTPase activating protein, HP, KIAA1723, p122-RhoGAP, RhoGAP, STARD12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- SRPBCC domain
- SH2-domain binding
- SAM domain
- SAM (Sterile alpha motif )
- enzyme binding
- GTPase activator
- central domain
- vinculin binding
- Cdk5 phosphorylation site
- protein binding
- GTPase Activating Protein domain
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- phospholipase activator
- Sterile alpha motif
- polybasic region
- SAM domain (Sterile alpha motif)
Pathways
Biological processes and signaling networks where the Dlc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- lung adenocarcinoma formation
- lung carcinoma process
- epithelial cancer
- epithelial neoplasia
- neoplasia
- diabetic nephropathy
- metastasis
- digestive system cancer
role in cell
- expression in
- proliferation
- accumulation in
- growth
- binding in
- accumulation
- migration
- formation
- invasiveness
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cortical actin cytoskeleton
- cellular membrane
- focal adhesions
- Nucleus
- Endoplasmic Reticulum
- actin filaments
- cytosol
- membrane ruffles
- caveolae
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of Rho protein signal transduction
- negative regulation of Rho protein signal transduction
- signal transduction
- negative regulation of cell proliferation
- positive regulation of execution phase of apoptosis
- hindbrain morphogenesis
- negative regulation of focal adhesion assembly
- heart morphogenesis
- negative regulation of stress fiber assembly
- regulation of actin cytoskeleton organization
- forebrain development
- neural tube closure
- regulation of small GTPase mediated signal transduction
- apoptotic process
- positive regulation of protein dephosphorylation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- focal adhesion assembly
- actin cytoskeleton organization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- focal adhesion
- cytoplasm
- intracellular membrane-bounded organelle
- membrane raft
- ruffle membrane
- cytosol
- endoplasmic reticulum
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- lipid binding
- SH2 domain binding