Hspb3 Gene Summary [Rat]
Predicted to be located in nucleus. Predicted to be active in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 4. Orthologous to human HSPB3 (heat shock protein family B (small) member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspb3 |
| Official Name | heat shock protein family B (small) member 3 [Source:RGD Symbol;Acc:68345] |
| Ensembl ID | ENSRNOG00000010992 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small) member 3 |
| Synonyms | 2310035K17Rik, DHMN2C, heat shock protein 3, heat shock protein family B (small) member 3, HMN2C, HMND4, Hsbp3, HSPL27, spb3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-crystallin Hsps/p23-like
- Hsp20/alpha crystallin family
Pathways
Biological processes and signaling networks where the Hspb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- Alzheimer disease
- androgenic alopecia
- distal hereditary motor neuronopathy type IIC
- Charcot-Marie-Tooth disease type 2
- oral submucous fibrosis
role in cell
- production in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck