Serpina7 Gene Summary [Rat]
Enables hormone binding activity. Involved in several processes, including response to corticosterone; response to prostaglandin E; and response to vitamin A. Located in extracellular space. Biomarker of hyperthyroidism and hypothyroidism. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpina7 |
| Official Name | serpin family A member 7 [Source:RGD Symbol;Acc:619833] |
| Ensembl ID | ENSRNOG00000011081 |
| Bio databases IDs | |
| Aliases | serpin family A member 7 |
| Synonyms | C730040N12, C730040N12Rik, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7, serine (or cysteine) peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 7, serpin family A member 7, TBG, TBGQTL, THYROXINE-binding GLOBULIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpina7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- thyroid hormone transporter
- glycosylation site
- Serpin (serine protease inhibitor)
- transporter
Pathways
Biological processes and signaling networks where the Serpina7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- partial thyroxine-binding globulin deficiency
regulates
- luciferase reporter gene
- levothyroxine
- thyroid hormone
- hormone
- L-triiodothyronine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Mitochondria
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpina7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity