Uts2 Gene Summary [Rat]
Predicted to enable hormone activity. Involved in several processes, including regulation of blood pressure; regulation of circadian sleep/wake cycle; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uts2 |
| Official Name | urotensin 2 [Source:RGD Symbol;Acc:3930] |
| Ensembl ID | ENSRNOG00000018393 |
| Bio databases IDs | |
| Aliases | urotensin 2 |
| Synonyms | prepro-UII, PRO1068, UCN2, U-II, Urocortin 2, urotensin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uts2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Urotensin II
- hormone
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bradycardia
- idiopathic scoliosis
- myocardial dysfunction
- facioscapulohumeral muscular dystrophy
role in cell
- proliferation
- migration
- chemotaxis
- differentiation
- adhesion
- motility
- formation
- elevation in
- formation in
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uts2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- muscle contraction
- synaptic transmission
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular space
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity
- receptor binding