Dhcr7 Gene Summary [Rat]
Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhcr7 |
| Official Name | 7-dehydrocholesterol reductase [Source:RGD Symbol;Acc:621769] |
| Ensembl ID | ENSRNOG00000020776 |
| Bio databases IDs | |
| Aliases | 7-dehydrocholesterol reductase |
| Synonyms | 7-DEHYDROCHOLESTEROL REDUCTASE, 7-dehydrocholesterol δ(7)-reductase, 7DHCR, 7-DHC reductase, D7SR, FLJ10664, SLOS, STEROL delta7-REDUCTASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhcr7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP binding
- enzyme
- protein binding
- ether hydrolase
- 7-dehydrocholesterol reductase
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- diabetes mellitus
- obesity
- Huntington disease
- Smith-Lemli-Opitz syndrome
- hereditary disorder
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- expression in
- proliferation
- differentiation
- migration
- cell death
- neurogenesis
- invasion by
- accumulation in
- phosphorylation in
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhcr7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol biosynthetic process via lathosterol
- cholesterol biosynthetic process via desmosterol
- cholesterol biosynthetic process
- brassinosteroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- nuclear outer membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- 7-dehydrocholesterol reductase activity