Cntnap4 Gene Summary [Rat]
Predicted to enable PDZ domain binding activity. Predicted to be involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in dendrite and plasma membrane. Predicted to be active in GABA-ergic synapse and presynaptic membrane. Orthologous to human CNTNAP4 (contactin associated protein family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntnap4 |
| Official Name | contactin associated protein-like 4 [Source:RGD Symbol;Acc:1306459] |
| Ensembl ID | ENSRNOG00000011231 |
| Bio databases IDs | |
| Aliases | contactin associated protein-like 4 |
| Synonyms | CASPR4, contactin associated protein family member 4, contactin associated protein-like 4, E130114F09Rik |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cntnap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- LamG
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- F5/8 type C domain
- protein binding
- laminin G domain
- PDZ-domain binding
- EGF_CA
- FA58C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- metastasis
- motor dysfunction
- melanoma
- melanoma cancer
- advanced cancer
- cancer
- late-onset Alzheimer disease
role in cell
- expression in
- accumulation in
- phosphorylation in
- proliferation
- migration
- degeneration
- differentiation
- organization
- accumulation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- presynaptic membrane
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cntnap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- regulation of grooming behavior
- regulation of synaptic transmission, GABAergic
- regulation of synaptic transmission, dopaminergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cell projection