Slc37a4 Gene Summary [Rat]
Enables glucose-6-phosphate transmembrane transporter activity. Involved in glucose-6-phosphate transport; response to glucose; and response to nutrient. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIw; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc37a4 |
| Official Name | solute carrier family 37 member 4 [Source:RGD Symbol;Acc:62066] |
| Ensembl ID | ENSRNOG00000011361 |
| Bio databases IDs | |
| Aliases | solute carrier family 37 member 4 |
| Synonyms | CDG2W, G6PT, G6PT1, G6PT2, G6PT3, Glycogen Storage Disease Type Ib, GSD-1b, GSD1c, GSD1d, mG6PT, PRO0685, solute carrier family 37 (glucose-6-phosphate transporter), member 4, solute carrier family 37 member 4, SPX4, TRG-19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc37a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycerate transporter family protein
- glucose-6-phosphate transporter
- nitrite extrusion protein (nitrite facilitator)
- benzoate transport
- glycerol-3-phosphate transporter
- Major Facilitator Superfamily
- hexose-phosphate:inorganic phosphate antiporter
- Multidrug resistance protein
- protein binding
- transporter
- D-galactonate transporter
Pathways
Biological processes and signaling networks where the Slc37a4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glycogen storage disease type Ib
- congenital disorder of glycosylation type 2w
- glycogen storage disease type Ic
- growth failure
- hereditary disorder
- glycogen storage disease type I
- glycogen storage disease
- hepatic steatosis
- congenital disorders of glycosylation
- hypoglycemia
role in cell
- expression in
- cell viability
- vacuolation
- differentiation
- number
- homeostasis
- depletion in
- activation in
- vacuolation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc37a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- glucose-6-phosphate transport
- glucose metabolic process
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- glucose-6-phosphate transmembrane transporter activity