Casp4 Gene Summary [Rat]
Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of signal transduction; and response to bacterium. Predicted to act upstream of or within ectopic germ cell programmed cell death; positive regulation of cytokine production; and pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Orthologous to several human genes including CASP4 (caspase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp4 |
| Official Name | caspase 4 [Source:RGD Symbol;Acc:621757] |
| Ensembl ID | ENSRNOG00000033697 |
| Bio databases IDs | |
| Aliases | caspase 4 |
| Synonyms | CASP-11, Casp13, Caspase 11, Caspase 13, caspase 4, caspase 4, apoptosis-related cysteine peptidase, Caspl, ich-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- CASc
- Caspase recruitment domain
- cysteine endopeptidase
- lipid binding
- peptidase
- protein binding
- lipopolysaccharide binding
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Casp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- gastritis
- flu
- endotoxin shock response
- experimental autoimmune encephalomyelitis
- gait disturbance
- septic cardiomyopathy
- shock response
- tumorigenesis
- cerebral hemorrhage
role in cell
- activation in
- formation
- formation in
- apoptosis
- replication in
- cell death
- number
- loss
- phosphorylation in
- proteolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- membrane processes
- perikaryon