Acsbg1 Gene Summary [Rat]
Predicted to enable long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid biosynthetic process and ovarian follicle atresia. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ACSBG1 (acyl-CoA synthetase bubblegum family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsbg1 |
| Official Name | acyl-CoA synthetase bubblegum family member 1 [Source:RGD Symbol;Acc:708557] |
| Ensembl ID | ENSRNOG00000011381 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase bubblegum family member 1 |
| Synonyms | acyl-CoA synthetase bubblegum family member 1, BG, BG1, BGM, E230019G03Rik, Gm2069, GR-LACS, LPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsbg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- AMP-binding enzyme
- CoA-ligase
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- Adenylate forming domain, Class I superfamily
- enzyme
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsbg1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- schizophrenia
- androgenic alopecia
- senile lentigo
- suicide attempt
regulates
- testosterone
- palmitic acid
- SNCA
- nervonic acid
- stearic acid
- erucic acid
- acyl CoA synthetase
- ceramide
- linoleic acid
- fatty acid
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- peroxisomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsbg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid metabolic process
- long-chain fatty acid biosynthetic process
- response to glucocorticoid stimulus
- long-chain fatty-acyl-CoA biosynthetic process
- myelination
- very long-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic vesicle
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- very long-chain fatty acid-CoA ligase activity
- long-chain fatty acid-CoA ligase activity