Akap2 Gene Summary [Rat]
Enables protein domain specific binding activity. Predicted to be involved in regulation of cell shape. Predicted to act upstream of or within actin filament organization; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Part of protein-containing complex. Orthologous to human PALM2AKAP2 (PALM2 and AKAP2 fusion). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap2 |
| Official Name | A-kinase anchoring protein 2 [Source:RGD Symbol;Acc:1305135] |
| Ensembl ID | ENSRNOG00000011504 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 2 |
| Synonyms | 53-H12, AA959716, AI649048, AKAP-2, AKAP-KL, B130066I24, B230340M18RIK, Gm20459, MISP2, Pakap, PALM2, PALM2 and AKAP2 fusion, paralemmin A kinase anchor protein, pEN70, PRKA2, R75368 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- binding protein
- protein domain specific binding
- protein binding
- MIU-linker domain found in unconventional myosin-VI
Pathways
Biological processes and signaling networks where the Akap2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- organismal death
- COVID-19
- colorectal cancer
- diabetic retinopathy
- refractive error
- plantar wart
- idiopathic pulmonary fibrosis
- acute myeloid leukemia
regulates
role in cell
- phosphorylation in
- formation
- migration
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- actin cytoskeleton
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
Cellular Component
Where in the cell the gene product is active
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding