Pakap Gene Summary [Mouse]
This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Pakap |
| Official Name | paralemmin A kinase anchor protein [Source:MGI Symbol;Acc:MGI:5141924] |
| Ensembl ID | ENSMUSG00000038729 |
| Bio databases IDs | |
| Aliases | paralemmin A kinase anchor protein |
| Synonyms | 53-H12, AA959716, AI649048, AKAP-2, AKAP-KL, B130066I24, B230340M18RIK, Gm20459, MISP2, Pakap, PALM2, PALM2 and AKAP2 fusion, paralemmin A kinase anchor protein, pEN70, PRKA2, R75368 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pakap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- binding protein
- protein domain specific binding
- protein binding
- MIU-linker domain found in unconventional myosin-VI
Pathways
Biological processes and signaling networks where the Pakap gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- organismal death
- COVID-19
- colorectal cancer
- diabetic retinopathy
- refractive error
- plantar wart
- idiopathic pulmonary fibrosis
- acute myeloid leukemia
regulates
role in cell
- phosphorylation in
- formation
- migration
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- actin cytoskeleton
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pakap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
Cellular Component
Where in the cell the gene product is active
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding