Epb42 Gene Summary [Rat]
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to act upstream of or within several processes, including hemoglobin metabolic process; multicellular organismal-level iron ion homeostasis; and spleen development. Predicted to be located in cortical cytoskeleton and membrane. Predicted to be part of ankyrin-1 complex. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 5. Orthologous to human EPB42 (erythrocyte membrane protein band 4.2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epb42 |
| Official Name | erythrocyte membrane protein band 4.2 [Source:RGD Symbol;Acc:1305306] |
| Ensembl ID | ENSRNOG00000011649 |
| Bio databases IDs | |
| Aliases | erythrocyte membrane protein band 4.2 |
| Synonyms | BAND4.2, Epb4.2, erythrocyte membrane protein band 4.2, P4.2, PA, SPH5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epb42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- structural constituent of cytoskeleton
- ATP binding
- protein binding
- Transglutaminase family, C-terminal ig like domain
- transporter
- Transglutaminase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary spherocytosis type 5
- osteoporosis
- sickle cell anemia
- anemia
- COVID-19
- aortic valve calcification
- Alzheimer disease
- papillary thyroid carcinoma
- papillary thyroid cancer
- hereditary spherocytosis
role in cell
- expression in
- quantity
- number
- attachment
- release
- morphogenesis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical cytoskeleton
- cytoskeleton
- intracellular space
- cellular membrane
- Nucleus
- erythrocyte membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epb42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- multicellular organismal iron ion homeostasis
- cytoskeleton organization
- cell morphogenesis
- spleen development
- peptide cross-linking
- hemoglobin metabolic process
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- plasma membrane
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein-glutamine gamma-glutamyltransferase activity
- protein binding
- structural constituent of cytoskeleton