Spink7 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Orthologous to human SPINK7 (serine peptidase inhibitor Kazal type 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spink7 |
| Official Name | serine peptidase inhibitor, Kazal type 7 [Source:RGD Symbol;Acc:1303077] |
| Ensembl ID | ENSRNOG00000032873 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor, Kazal type 7 |
| Synonyms | ECG2, ECRG-2, EG408198, serine peptidase inhibitor Kazal type 7, serine peptidase inhibitor, Kazal type 7, serine peptidase inhibitor, Kazal type 7 (putative) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spink7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- KAZAL_FS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- endometrial cancer
- T-cell leukemia
- colon cancer
- skin cancer
- pancreatic cancer
- gastric cancer
- lung cancer
- large intestine carcinoma
- large intestine cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- migration
- growth
- binding in
- activation in
- degradation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spink7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding