Ptprm Gene Summary [Rat]
Predicted to enable cadherin binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and retinal ganglion cell axon guidance. Predicted to act upstream of or within vasodilation. Predicted to be located in several cellular components, including adherens junction; lamellipodium; and perinuclear region of cytoplasm. Predicted to be active in cell-cell junction. Orthologous to human PTPRM (protein tyrosine phosphatase receptor type M). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprm |
| Official Name | protein tyrosine phosphatase, receptor type, M [Source:RGD Symbol;Acc:620776] |
| Ensembl ID | ENSRNOG00000011700 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, M |
| Synonyms | hR-PTPu, mKIAA4044, protein tyrosine phosphatase receptor type M, protein tyrosine phosphatase, receptor type, M, Ptp mu, PTPRL1, RPTPM, R-PTP-MU, RPTPU |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptprm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- wedge domain
- Protein tyrosine phosphatase, catalytic domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- identical protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- cytoplasmic domain
- Immunoglobulin like
- phosphatase
- intracellular domain
- cadherin binding
- MAM domain, meprin/A5/mu
- extracellular domain
- catalytic domain
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- phosphatase domain
- PTPase domain
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- FN3
- transmembrane receptor protein tyrosine phosphatase
- transmembrane domain
Pathways
Biological processes and signaling networks where the Ptprm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- schizophrenia
- rheumatoid arthritis
- organismal death
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- chronic lymphocytic leukemia
role in cell
- expression in
- binding
- cell viability
- survival
- invasion by
- migration
- differentiation
- proliferation
- morphogenesis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- intercellular junctions
- cell-cell adherens junctions
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptprm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- retinal ganglion cell axon guidance
- signal transduction
- neuron projection development
- protein dephosphorylation
- retina layer formation
- negative regulation of endothelial cell proliferation
- homophilic cell adhesion
- response to xenobiotic stimulus
- negative regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell-cell junction
- perinuclear region of cytoplasm
- cytoplasm
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein tyrosine phosphatase activity
- cadherin binding
- phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity