Btg1 Gene Summary [Rat]
Predicted to enable enzyme binding activity. Involved in response to oxidative stress; response to peptide hormone; and spermatogenesis. Predicted to be active in cytoplasm and nucleus. Biomarker of protein-energy malnutrition. Orthologous to human BTG1 (BTG anti-proliferation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btg1 |
| Official Name | BTG anti-proliferation factor 1 [Source:RGD Symbol;Acc:2224] |
| Ensembl ID | ENSRNOG00000004284 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 1 |
| Synonyms | AI426953, APRO2, BTG anti-proliferation factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Btg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- transcription regulator
- LXXLL motif
- enzyme binding
- protein binding
- BoxC domain
- Box B domain
- phosphorylation site
- tob/btg1 family
Pathways
Biological processes and signaling networks where the Btg1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- peripheral T-cell lymphoma
- advanced cancer
- insulin resistance
- major depression
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- limited-stage typical follicular lymphoma
- precursor B-cell acute lymphoblastic leukemia
role in cell
- expression in
- apoptosis
- cell death
- growth
- signaling in
- proliferation
- differentiation
- dissemination
- motility
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Btg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of cell growth
- negative regulation of cell proliferation
- positive regulation of fibroblast apoptotic process
- regulation of transcription, DNA-dependent
- negative regulation of mitotic cell cycle
- positive regulation of myoblast differentiation
- positive regulation of endothelial cell differentiation
- cell migration
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- kinase binding
- enzyme binding