Agmat Gene Summary [Rat]
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines. Predicted to be involved in putrescine biosynthetic process from arginine, via agmatine. Predicted to be located in mitochondrion. Orthologous to human AGMAT (agmatinase (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agmat |
| Official Name | agmatinase [Source:RGD Symbol;Acc:1308424] |
| Ensembl ID | ENSRNOG00000012315 |
| Bio databases IDs | |
| Aliases | agmatinase |
| Synonyms | 5033405N08Rik, agmatinase, agmatinase (putative), LOC100507192, LOC102548844 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agmat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanidinobutyrase
- guanidinopropionase
- arginase
- enzyme
- protein binding
- agmatinase
- Arginase-like and histone-like hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- Moyamoya disease
- hepatocellular carcinoma
- gout
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agmat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- agmatine biosynthetic process
- urea cycle
- putrescine biosynthetic process from arginine, using agmatinase
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- guanidinopropionase activity
- metal ion binding
- guanidinobutyrase activity
- arginase activity
- agmatinase activity