Lgi1 Gene Summary [Rat]
Predicted to enable signaling receptor binding activity. Involved in positive regulation of synaptic transmission. Located in axon initial segment; dendrite; and extracellular space. Used to study epilepsy and epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgi1 |
| Official Name | leucine-rich, glioma inactivated 1 [Source:RGD Symbol;Acc:628742] |
| Ensembl ID | ENSRNOG00000014758 |
| Bio databases IDs | |
| Aliases | leucine-rich, glioma inactivated 1 |
| Synonyms | ADLTE, ADPAEF, ADPEAF, BB130740, EPITEMPIN, EPT, ETL1, IB1099, leucine rich glioma inactivated 1, leucine-rich, glioma inactivated 1, leucine-rich repeat LGI family, member 1, LOC100361792 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lgi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- leucine-rich repeat
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- EPTP domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant partial epilepsy with auditory features
- akinesia
- encephalitis
- seizures
- tonic-clonic seizure
- environmentally induced seizure
- tonic seizure
- growth failure
- hereditary disorder
- neurodegeneration
role in cell
- expression in
- growth
- pruning
- abnormal morphology
- invasiveness
- excitability
- pruning in
- synaptic transmission
- density
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- axon initial segments
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lgi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- neuron projection development
- positive regulation of synaptic transmission
- nervous system development
- axon guidance
Cellular Component
Where in the cell the gene product is active
- dendrite
- initial segment
- extracellular space
- synaptic cleft
- cytoplasm
- Golgi apparatus
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding