Ppp1r13b Gene Summary [Rat]
Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Located in perinuclear region of cytoplasm. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r13b |
| Official Name | protein phosphatase 1, regulatory subunit 13B [Source:RGD Symbol;Acc:1304651] |
| Ensembl ID | ENSRNOG00000012653 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 13B |
| Synonyms | ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B, protein phosphatase 1, regulatory subunit 13B, Tp53bp2, Trp53bp2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- polo kinase kinase
- Ankyrin repeats (many copies)
- MAPK-interacting and spindle-stabilising protein-like
- Ubl1_cv_Nsp3_N-like
- phosphatase
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- ankyrin repeats
- Gametogenetin
Pathways
Biological processes and signaling networks where the Ppp1r13b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- schizophrenia
- prostate cancer
- COVID-19
- metabolic syndrome X
- insomnia
- prostatic carcinoma
- substance-related disorder
- bipolar disorder
role in cell
- apoptosis
- growth
- expression in
- cell death
- synthesis in
- senescence
- cell cycle progression
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of cell cycle
- regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding