C1qb Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in response to glucocorticoid. Located in synapse. Part of complement component C1 complex. Biomarker of ocular hypertension. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qb |
| Official Name | complement C1q B chain [Source:RGD Symbol;Acc:2229] |
| Ensembl ID | ENSRNOG00000012749 |
| Bio databases IDs | |
| Aliases | complement C1q B chain |
| Synonyms | Adia, C1q Beta-Chain, C1QD2, C1q β-Chain, complement C1q B chain, complement component 1, q subcomponent, beta polypeptide, complement component 1, q subcomponent, β polypeptide |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1qb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Collagen triple helix repeat (20 copies)
- protein binding
- identical protein binding
- globular head domain
- C1q domain
Pathways
Biological processes and signaling networks where the C1qb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- septic shock
- sepsis
- complement component C1q deficiency type 2
- tuberculosis
- colorectal cancer
- lupus erythematosus
- complement component C1q deficiency
- diabetic nephropathy
- laser induced choroidal neovascularization
regulates
- S
- Complement component 1
role in cell
- pruning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1qb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- innate immune response
- complement activation, classical pathway
Cellular Component
Where in the cell the gene product is active
- complement component C1 complex
- collagen
- blood microparticle
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding