Add3 Gene Summary [Rat]
Enables protein kinase C binding activity. Involved in positive regulation of cytoskeleton organization; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including brush border; cell-cell junction; and condensed nuclear chromosome. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Used to study hypertension and proteinuria. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 3. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Add3 |
| Official Name | adducin 3 [Source:RGD Symbol;Acc:2043] |
| Ensembl ID | ENSRNOG00000012820 |
| Bio databases IDs | |
| Aliases | adducin 3 |
| Synonyms | 35H, ADDL, adducin 3, Adducin-gamma, Adducin-γ, CPSQ3, gamma ADDUCIN, γ ADDUCIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Add3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldolase_II
- structural constituent of cytoskeleton
- Class II Aldolase and Adducin N-terminal domain
- protein kinase C binding
- protein binding
- methylthioribulose-1-phosphate dehydratase
Pathways
Biological processes and signaling networks where the Add3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- precursor B-cell acute lymphoblastic leukemia
- cutaneous melanoma
- cutaneous melanoma cancer
- anisopoikilocytosis
- spastic quadriplegic cerebral palsy type 3
- idiopathic scoliosis
- refractive error
- Parkinson disease
- bipolar disorder
role in cell
- expression in
- quantity
- disruption
- loss in
- adhesion
- abnormal morphology
- organization
- disruption in
- replicative senescence
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- cytoskeleton
- cellular membrane
- cell cortex
- Plasma Membrane
- intercellular junctions
- cytosol
- microsome
- chromosome
- brush border
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Add3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- positive regulation of cytoskeleton organization
- cytoskeleton organization
- positive regulation of vasoconstriction
- response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoskeleton
- cell-cell junction
- brush border
- cell cortex
- membrane
- cytosol
- plasma membrane
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- actin filament binding
- calmodulin binding
- structural constituent of cytoskeleton