Trpm2 Gene Summary [Rat]
Predicted to enable calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of cellular response to oxidative stress. Located in neuronal cell body. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpm2 |
| Official Name | transient receptor potential cation channel, subfamily M, member 2 [Source:RGD Symbol;Acc:1311889] |
| Ensembl ID | ENSRNOG00000001216 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily M, member 2 |
| Synonyms | 9830168K16Rik, C79133, EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, transient receptor potential cation channel subfamily M member 2, transient receptor potential cation channel, subfamily M, member 2, Trp7, TRPC7, Trpm2-predicted, Trrp7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trpm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- SLOG in TRPM
- manganese ion transporter
- calcium channel
- NudT9 homology domain
- calcium ion binding
- ligand-gated ion channel
- ion channel
- calcium-release channel
- cation channel
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- transitional cell bladder cancer
- liver cancer
- cancer
- epithelial cancer
- neoplasia
- renal cell cancer
- hepatocellular carcinoma
- thermal hyperalgesia
role in cell
- infiltration by
- phosphorylation in
- expression in
- function
- quantity
- proliferation
- activation in
- production in
- differentiation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
- lysosome
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- lysosome membrane
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trpm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hydroperoxide
- response to purine-containing compound
- regulation of filopodium assembly
- response to heat
- regulation of actin cytoskeleton organization
- protein homotetramerization
- cellular response to calcium ion
- manganese ion transmembrane transport
- temperature homeostasis
- dendritic cell chemotaxis
- calcium ion transport
- dendritic cell differentiation
- calcium ion transmembrane transport
- cellular response to temperature stimulus
- sodium ion transmembrane transport
- zinc ion transmembrane transport
- cellular response to hydrogen peroxide
- release of sequestered calcium ion into cytosol
- calcium-mediated signaling
- cellular response to purine-containing compound
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- perikaryon
- cell projection
- tertiary granule membrane
- plasma membrane
- lysosomal membrane
- lysosome
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- mono-ADP-D-ribose binding
- calcium-release channel activity
- ADP-ribose diphosphatase activity
- calcium ion binding
- calcium channel activity
- sodium channel activity
- cation channel activity
- manganese ion transmembrane transporter activity
- hydrolase activity