Hk1 Gene Summary [Rat]
Enables several functions, including ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hk1 |
| Official Name | hexokinase 1 [Source:RGD Symbol;Acc:2796] |
| Ensembl ID | ENSRNOG00000046891 |
| Bio databases IDs | |
| Aliases | hexokinase 1 |
| Synonyms | CNSHA5, dea, HEXOKIN, hexokinase, hexokinase 1, HK, Hk1-s, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, mHk1-s, NEDVIBA, NMSR, RP79 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mitochondrial presequence
- protein kinase
- regulatory domain
- catalytic domain
- ATP binding
- glucose binding
- PLN02914
- glucokinase
- fructokinase
- protein binding
- identical protein binding
- kinase
- binding protein
- peptidoglycan binding
- mannokinase
- hexokinase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- limited systemic sclerosis
- colorectal cancer
- hyperlipidemia
- metabolic disorder
- hereditary disorder
- retinal dystrophy
- neurodevelopmental disorder with visual defects and brain anomalies
role in cell
- growth
- cell viability
- apoptosis
- proliferation
- phosphorylation in
- cell death
- production in
- migration
- permeability
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell periphery
- cellular membrane
- Mitochondria
- granules
- cytosol
- caveolae
- mitochondrial outer membrane
- cytoplasmic droplets
- Z line
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycolysis
- mannose metabolic process
- fructose 6-phosphate metabolic process
- glucose metabolic process
- carbohydrate phosphorylation
- positive regulation of cytokine production involved in immune response
- glucose 6-phosphate metabolic process
- inflammatory response
- cellular glucose homeostasis
- innate immune response
- maintenance of protein location in mitochondrion
- establishment of protein localization in mitochondrion
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- membrane raft
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- ATP binding
- peptidoglycan binding
- protein binding
- glucokinase activity
- glucosamine kinase activity
- mannokinase activity
- hexokinase activity
- fructokinase activity