Drd1 Gene Summary [Rat]
Enables several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and regulation of protein phosphorylation. Located in several cellular components, including caveola; dendrite; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study Parkinson's disease; alcohol dependence; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; neurodegenerative disease (multiple); tracheal stenosis; traumatic brain injury; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Drd1 |
| Official Name | dopamine receptor D1 [Source:RGD Symbol;Acc:2518] |
| Ensembl ID | ENSRNOG00000023688 |
| Bio databases IDs | |
| Aliases | dopamine receptor D1 |
| Synonyms | C030036C15Rik, D1, D1a, D1DR, D1R, D1 receptor, D1 receptors, Da-d1 receptor, DADR, Dopamine d1 receptor, dopamine receptor D1, DR1, DRD1A, Gpcr15 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Drd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- protein phosphatase binding
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- dopamine D1 receptor-like receptor
- seven-transmembrane G protein-coupled receptor superfamily
- ATPase binding
- binding protein
- cytoplasmic domain
- cytoplasmic loop
- dopamine receptor
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
Pathways
Biological processes and signaling networks where the Drd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- vomiting
- neoplasia
- weight gain
- nausea
- lung cancer
- COVID-19
- infection
- shock response
- diabetes mellitus
- impaired glucose tolerance
role in cell
- differentiation
- phosphorylation in
- migration
- activation in
- production in
- expression in
- binding in
- proliferation
- quantity
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- endomembrane system
- non-motile cilium
- Cytoplasm
- presynaptic regions
- cilia
- cell surface
- cell borders
- perinuclear region
- intracellular membranes
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- presynaptic membrane
- postsynaptic membrane
- caveolae
- perinuclear space
- dendritic spines
- dendritic spine neck
- dendritic spine head
- neurites
- dendritic trees
- synapse
- membrane rafts
- brush border
- perikaryon
- axons
- dendrites
- axon terminals
- presynaptic terminals
- dendritic shafts
- axon branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Drd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine transport
- dopamine metabolic process
- dopamine receptor signaling pathway
- visual learning
- positive regulation of potassium ion transport
- striatum development
- memory
- long-term synaptic potentiation
- long term synaptic depression
- positive regulation of synaptic transmission, glutamatergic
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating dopamine receptor signaling pathway
- dentate gyrus development
- mating behavior
- synapse assembly
- protein import into nucleus
- adenylate cyclase-activating adrenergic receptor signaling pathway
- positive regulation of cell migration
- operant conditioning
- astrocyte development
- adenylate cyclase-activating dopamine receptor signaling pathway
- habituation
- cerebral cortex GABAergic interneuron migration
- vasodilation
- response to xenobiotic stimulus
- maternal behavior
- adult walking behavior
- grooming behavior
- synaptic transmission, dopaminergic
- behavioral response to cocaine
- sensitization
- regulation of dopamine uptake involved in synaptic transmission
- cellular response to catecholamine stimulus
- activation of adenylate cyclase activity
- transmission of nerve impulse
- positive regulation of neuron migration
- regulation of action potential in neuron
- prepulse inhibition
- glucose import
- positive regulation of release of sequestered calcium ion into cytosol
- positive regulation of MAPK cascade
- conditioned taste aversion
- behavioral fear response
- response to amphetamine
- regulation of protein phosphorylation
- regulation of dopamine metabolic process
- temperature homeostasis
- peristalsis
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- presynaptic membrane
- nucleus
- postsynaptic membrane
- dendritic spine
- cilium
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- dopamine receptor activity
- G-protein coupled receptor activity
- dopamine receptor activity, coupled via Gs
- protein binding
- G-protein alpha-subunit binding
- dopamine binding
- heterotrimeric G-protein binding