Enpp1 Gene Summary [Rat]
Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in dendrite; neuronal cell body; and plasma membrane. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enpp1 |
| Official Name | ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:RGD Symbol;Acc:628825] |
| Ensembl ID | ENSRNOG00000013994 |
| Bio databases IDs | |
| Aliases | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| Synonyms | 4833416E15RIK, ARHR2, CD203c, COLED, ectonucleotide pyrophosphatase/phosphodiesterase 1, Ly-41, M6S1, NPP1, NPPS, PC-1, Pca, PCA1, PDNP1, ttw, twy |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Enpp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphodiesterase I
- Type I phosphodiesterase / nucleotide pyrophosphatase
- alkaline phosphatases and sulfatases
- insulin receptor binding
- DNA/RNA non-specific endonuclease
- phosphorous-containing acid anhydride hydrolase
- nucleoside-triphosphate diphosphatase
- ATP binding
- calcium ion binding
- enzyme
- protein binding
- Somatomedin B domain
- identical protein binding
- zinc ion binding
- NUC
- exonuclease
- pyrophosphatase
- nucleotide diphosphatase
- phosphatase
- protein homodimerization
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Enpp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- mammary neoplasm
- obesity
- generalized arterial calcification of infancy type 1
- medial coronary sclerosis of infancy
- autosomal recessive hypophosphatemic rickets type 2
- osteoporosis
- Cole disease
role in cell
- expression in
- function
- calcification
- apoptosis
- growth
- proliferation
- glycolysis in
- differentiation
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- matrix vesicles
- cellular protrusions
- perikaryon
- dendrites
- plasma
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Enpp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- negative regulation of bone mineralization
- inorganic diphosphate transport
- immune response
- vesicle-mediated transport
- negative regulation of cell growth
- negative regulation of protein autophosphorylation
- cellular phosphate ion homeostasis
- regulation of bone mineralization
- nucleic acid metabolic process
- phosphate ion homeostasis
- generation of precursor metabolites and energy
- bone mineralization
- response to ATP
- nucleoside triphosphate catabolic process
- negative regulation of glycogen biosynthetic process
- negative regulation of glucose import
- negative regulation of fat cell differentiation
- negative regulation of insulin receptor signaling pathway
- phosphate-containing compound metabolic process
- melanocyte differentiation
- ATP metabolic process
- gene expression
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- sequestering of triglyceride
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- basolateral plasma membrane
- plasma membrane
- lysosomal membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- UTP diphosphatase activity
- zinc ion binding
- protein homodimerization activity
- scavenger receptor activity
- nucleotide diphosphatase activity
- insulin receptor binding
- nucleoside-triphosphate diphosphatase activity
- 3',5'-cyclic-AMP phosphodiesterase activity
- nucleic acid binding
- ATP diphosphatase activity
- ATP binding
- protein binding
- phosphodiesterase I activity
- exonuclease activity
- calcium ion binding
- phosphatase activity
- GTP diphosphatase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding
- polysaccharide binding