Slc27a4 Gene Summary [Rat]
Predicted to enable fatty acid-CoA ligase activity and long-chain fatty acid transmembrane transporter activity. Involved in response to nutrient. Predicted to be located in brush border membrane; endoplasmic reticulum; and microvillus. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Biomarker of steatotic liver disease. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a4 |
| Official Name | solute carrier family 27 member 4 [Source:RGD Symbol;Acc:1307383] |
| Ensembl ID | ENSRNOG00000014369 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 member 4 |
| Synonyms | ACSVL4, FATP4, IPS, solute carrier family 27 (fatty acid transporter), member 4, solute carrier family 27 member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc27a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty acid transporter
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- protein binding
- acyl-CoA synthetase domain
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- long-chain fatty acid transporter
- AMP-binding enzyme
- CoA-ligase
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
- transporter
Pathways
Biological processes and signaling networks where the Slc27a4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyspnea
- lamellar ichthyosis
- hereditary disorder
- ichthyosis prematurity syndrome
- wrinkle-free skin disease
- hyperkeratosis
- diabetes mellitus
- dystrophy
- weight gain
- dermatological disorder
regulates
- PPARG
- trans-2-hexadecenoyl-coenzyme A
- palmitoyl-coenzyme A
- coenzyme A
- lignoceric acid
- d18:1/25:0 ceramide
- lignoceroyl-coenzyme A
- palmitic acid
- very long chain fatty acid
- sphingomyelin
role in cell
- apoptosis
- function
- size
- quantity
- formation
- lipolysis in
- circumference
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- endoplasmic reticulum fraction
- detergent-soluble membrane fractions
- cholesterol-rich microdomain
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondria-associated membranes
- apical vacuoles
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc27a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- very long-chain fatty acid catabolic process
- response to nutrient
- skin development
- negative regulation of insulin receptor signaling pathway
- fatty acid metabolic process
- long-chain fatty acid metabolic process
- glucose import in response to insulin stimulus
- long-chain fatty acid transport
- medium-chain fatty acid transport
- fatty acid transport
- positive regulation of apoptotic process
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- brush border membrane
- microvillus
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- very long-chain fatty acid-CoA ligase activity
- fatty acid transporter activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity
- long-chain fatty acid transporter activity