Chrnb4 Gene Summary [Rat]
Enables acetylcholine binding activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including membrane depolarization; positive regulation of transmission of nerve impulse; and synaptic signaling. Predicted to act upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic transmission involved in micturition. Located in plasma membrane. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); nicotine dependence; and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrnb4 |
| Official Name | cholinergic receptor nicotinic beta 4 subunit [Source:RGD Symbol;Acc:2351] |
| Ensembl ID | ENSRNOG00000014427 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic beta 4 subunit |
| Synonyms | Acrb-4, cholinergic receptor nicotinic beta 4 subunit, cholinergic receptor, nicotinic, beta polypeptide 4, cholinergic receptor nicotinic β 4 subunit, cholinergic receptor, nicotinic, β polypeptide 4, nAChR beta4, Nicotinic acetylcholine receptor β 4 subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrnb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- intracellular loop
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- acetylcholine receptor
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- transmembrane domain
- ligand-gated ion channel
- acetylcholine binding
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrnb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- tobacco-related disorder
- nicotine dependence
- coronary artery disease
- renal failure
- acute respiratory distress syndrome
- paralysis
- schizophrenia
- nicotine withdrawal syndrome
- sudden cardiac arrest
role in cell
- transmembrane potential
- response
- inhibition in
- synaptic transmission
- excitation
- recovery in
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- tertiary granule membrane
- specific granule membrane
- synaptic membrane
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrnb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- synaptic transmission involved in micturition
- behavioral response to nicotine
- signal transduction
- ion transmembrane transport
- synaptic transmission
- regulation of smooth muscle contraction
- ion transport
- locomotory behavior
- positive regulation of transmission of nerve impulse
- smooth muscle contraction
- membrane depolarization
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- membrane
- synapse
- acetylcholine-gated channel complex
- neuron projection
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor activity
- ligand-gated ion channel activity
- acetylcholine-gated cation channel activity