Ap1m1 Gene Summary [Rat]
Predicted to enable clathrin adaptor activity. Predicted to be involved in endosome to melanosome transport; melanosome organization; and vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle and synapse. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap1m1 |
| Official Name | adaptor related protein complex 1 subunit mu 1 [Source:RGD Symbol;Acc:1307653] |
| Ensembl ID | ENSRNOG00000014454 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 1 subunit mu 1 |
| Synonyms | adaptor related protein complex 1 subunit mu 1, adaptor-related protein complex AP-1, mu subunit 1, Adtm1A, AP47, CLAPM2, CLTNM, MU-1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap1m1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine binding pocket
- AP_MHD_Cterm
- Adaptor complexes medium subunit family
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap1m1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- gastric adenocarcinoma
- gastric epithelial cancer
- cutaneous melanoma
- cutaneous melanoma cancer
role in cell
- expression in
- binding in
- organization
- processing in
- assembly in
- accumulation in
- amidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- perinuclear region
- Plasma Membrane
- endosomes
- Golgi Apparatus
- specific granule membrane
- cytosol
- Golgi membrane
- trans Golgi network
- lysosome membrane
- synapse
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap1m1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- melanosome organization
- vesicle-mediated transport
- endosome to melanosome transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- lysosomal membrane
- plasma membrane
- cytoplasmic vesicle membrane
- early endosome
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- AP-1 adaptor complex
- cytosol
- clathrin-coated vesicle
- trans-Golgi network membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin adaptor activity