Fndc3a Gene Summary [Rat]
Predicted to be involved in spermatid development. Predicted to act upstream of or within Sertoli cell development; cell-cell adhesion; and fertilization. Predicted to be located in several cellular components, including Golgi apparatus; acrosomal vesicle; and vesicle membrane. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human FNDC3A (fibronectin type III domain containing 3A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fndc3a |
| Official Name | fibronectin type III domain containing 3a [Source:RGD Symbol;Acc:1304736] |
| Ensembl ID | ENSRNOG00000014478 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 3a |
| Synonyms | 1700094E19Rik, bA203I16.1, bA203I16.5, D14Ertd453e, F730017H24Rik, Fibronectin Type III Domain Containing 3, fibronectin type III domain containing 3A, FND3A, FNDC3, HUGO, KIAA0970, sys |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fndc3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Purple acid Phosphatase, N-terminal domain
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- Crohn disease
- uterine leiomyoma
- leiomyomatosis
- inflammatory bowel disease
- myasthenia gravis
- hypogonadotropic hypogonadism
regulates
role in cell
- apoptosis
- development
- transcription in
- accumulation in
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- vesicle membrane
- acrosome
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fndc3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- fertilization
- Sertoli cell development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- vesicle membrane
- intracellular membrane-bounded organelle
- acrosomal vesicle
- membrane
- cytosol
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- RNA binding