Edn3 Gene Summary [Rat]
Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome; and Waardenburg syndrome type 4B. Orthologous to human EDN3 (endothelin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Edn3 |
| Official Name | endothelin 3 [Source:RGD Symbol;Acc:2534] |
| Ensembl ID | ENSRNOG00000007477 |
| Bio databases IDs | |
| Aliases | endothelin 3 |
| Synonyms | endothelin 3, ET-3, HSCR4, ls, PPET3, preproET-3, RGD1564825, tmgc48, WS4B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Edn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endothelin family
- G-protein-coupled receptor binding
- hormone
- receptor binding
Pathways
Biological processes and signaling networks where the Edn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- cancer
- Waardenburg syndrome type 4B
- endometriosis
- susceptibility to Hirschsprung disease type 4
- Hirschsprung disease
- biliary atresia
- sensorineural hearing loss
- polyarticular juvenile rheumatoid arthritis
- colorectal adenoma
role in cell
- expression in
- proliferation
- activation in
- quantity
- differentiation
- adhesion
- mitogenesis
- mitosis
- migration
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Edn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of heart rate
- cell proliferation
- positive regulation of prostaglandin-endoperoxide synthase activity
- peptide hormone secretion
- positive regulation of cell proliferation
- axon guidance
- vasoconstriction
- positive regulation of mitosis
- establishment of localization in cell
- regulation of vasoconstriction
- potassium ion transmembrane transport
- signal transduction
- cell-cell signaling
- blood circulation
- positive regulation of leukocyte chemotaxis
- positive regulation of hormone secretion
- cell surface receptor signaling pathway
- positive regulation of cell differentiation
- regulation of systemic arterial blood pressure by endothelin
- cellular calcium ion homeostasis
- melanocyte differentiation
- neural crest cell migration
- axon extension
- regulation of developmental pigmentation
- regulation of gene expression
- vein smooth muscle contraction
- neutrophil chemotaxis
- artery smooth muscle contraction
- cellular magnesium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- endothelin B receptor binding
- receptor binding
- hormone activity