Adam28 Gene Summary [Rat]
Predicted to enable immunoglobulin receptor binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in cell surface. Human ortholog(s) of this gene implicated in breast cancer; estrogen-receptor positive breast cancer; invasive ductal carcinoma; lung adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam28 |
| Official Name | ADAM metallopeptidase domain 28 [Source:RGD Symbol;Acc:727820] |
| Ensembl ID | ENSRNOG00000014518 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 28 |
| Synonyms | ADAM metallopeptidase domain 28, a disintegrin and metallopeptidase domain 28, C130072N01RIK, D430033C21Rik, Dtgn1, eMDC II, MDC-L, TECADAM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- metalloprotease domain
- peptidase
- signal peptide
- secreted-specific domain
- protein binding
- receptor binding
- disintergrin domain
- metallopeptidase
- ZnMc
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- disintegrin-like domain
- pro domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Adam28 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- organismal death
- lung cancer
- renal cell cancer
- breast carcinoma
- cleft palate
- renal cell carcinoma
- hereditary spastic paraplegia
role in cell
- proliferation
- adhesion
- degradation in
- number
- binding
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- proteolysis
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity
- immunoglobulin receptor binding
- metallopeptidase activity