Hbs1l Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including central nervous system; limb muscle; liver; lung; and spleen. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hbs1l |
| Official Name | Hbs1-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1891704] |
| Ensembl ID | ENSMUSG00000019977 |
| Bio databases IDs | |
| Aliases | Hbs1-like (S. cerevisiae) |
| Synonyms | 2810035F15Rik, EF-1a, eRF3c, ERFS, HBS1, Hbs1-like (S. cerevisiae), HBS1-like translational GTPase, HSPC276 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hbs1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Elongation factor Tu C-terminal domain
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- GTP binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- sulfate adenylyltransferase, large subunit
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- HBS1 N-terminus
- translation elongation factor TU
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Fetal hemoglobin
- gamma globin
disease
- benign prostatic hyperplasia
- Hodgkin lymphoma
- androgenic alopecia
- coronary artery disease
- hematological disorder
- hypercholesterolemia
- hypothyroidism
- osteoarthropathy
- autosomal dominant thrombocytopenia type 4
- Hodgkin disease
phenotypes
- abnormal bone structure
- abnormal retina morphology
- abnormal snout morphology
- abnormal tail morphology
- corneal opacity
- decreased Langerhans cell number
- decreased T-helper cell number
- decreased bone mineral content
- decreased bone mineral density
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased mature B cell number
- decreased memory-marker CD4-negative NK T cell number
- decreased monocyte cell number
- decreased total body fat amount
- improved glucose tolerance
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD5-positive gamma-delta T cell number
- increased circulating HDL cholesterol level
- increased circulating LDL cholesterol level
- increased circulating alkaline phosphatase level
- increased circulating cholesterol level
- increased circulating free fatty acid level
- increased circulating iron level
- increased circulating total protein level
- increased effector memory CD8-positive alpha-beta T cell number
- increased lean body mass
- increased mean corpuscular hemoglobin
- increased mean platelet volume
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased red blood cell distribution width
- increased regulatory T cell number
- male infertility
- thrombocytosis
- abnormal adipose tissue amount
- abnormal circulating LDL cholesterol level
- abnormal circulating alkaline phosphatase level
- abnormal circulating iron level
- abnormal circulating total protein level
- abnormal facial morphology
- abnormal lean body mass
- abnormal mean corpuscular hemoglobin
- abnormal nasal bone morphology
- abnormal platelet volume
- abnormal retinal pigmentation
- abnormal tooth morphology
- abnormal vertebrae morphology
- abnormal zygomatic bone morphology
- asymmetric snout
- decreased body weight
- malocclusion
- short nasal bone
- short snout
- vertebral transformation
role in cell
- expression in
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hbs1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- rescue of stalled ribosome
- signal transduction
- ribosome disassembly
- nuclear-transcribed mRNA catabolic process, no-go decay
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosolic ribosome
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- translation elongation factor activity
- GTPase activity