Dbr1 Gene Summary [Rat]
Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in RNA fragment catabolic process and RNA splicing, via transesterification reactions. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbr1 |
| Official Name | debranching RNA lariats 1 [Source:RGD Symbol;Acc:1598038] |
| Ensembl ID | ENSRNOG00000014588 |
| Bio databases IDs | |
| Aliases | debranching RNA lariats 1 |
| Synonyms | debranching RNA lariats 1, LOC683696, XGIP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dbr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lariat debranching enzyme, C-terminal domain
- enzyme
- RNA lariat debranching enzyme
- metallophosphatase superfamily, metallophosphatase domain
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to infection-induced (viral) acute encephalitis type 11
- xerosis and growth failure with immune and pulmonary dysfunction syndrome
- primary antiphospholipid antibody syndrome
- infection by vesicular stomatitis virus
- infection by human herpesvirus 1
role in cell
- phosphorylation in
- formation in
- expression in
- formation
- degradation in
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dbr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA fragment catabolic process
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA lariat debranching enzyme activity
- RNA binding
- metal ion binding