DBR1 Gene Summary [Human]
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | DBR1 |
| Official Name | debranching RNA lariats 1 [Source:HGNC Symbol;Acc:HGNC:15594] |
| Ensembl ID | ENSG00000138231 |
| Bio databases IDs | |
| Aliases | debranching RNA lariats 1 |
| Synonyms | debranching RNA lariats 1, LOC683696, XGIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DBR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lariat debranching enzyme, C-terminal domain
- enzyme
- RNA lariat debranching enzyme
- metallophosphatase superfamily, metallophosphatase domain
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to infection-induced (viral) acute encephalitis type 11
- xerosis and growth failure with immune and pulmonary dysfunction syndrome
- primary antiphospholipid antibody syndrome
- infection by vesicular stomatitis virus
- infection by human herpesvirus 1
role in cell
- phosphorylation in
- formation in
- expression in
- formation
- degradation in
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DBR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA fragment catabolic process
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA lariat debranching enzyme activity
- RNA binding
- metal ion binding