Grk6 Gene Summary [Rat]
Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grk6 |
| Official Name | G protein-coupled receptor kinase 6 [Source:RGD Symbol;Acc:61986] |
| Ensembl ID | ENSRNOG00000014615 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 6 |
| Synonyms | GPRK6, G protein-coupled receptor kinase 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- palmitoylation site
- Protein kinase (unclassified specificity)
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- beta-adrenergic-receptor kinase
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Protein kinase domain
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- G-protein coupled receptor kinase
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Grk6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- cancer
- epithelial neoplasia
- epithelial cancer
- lung carcinoma process
- thoracic cancer
- tinnitus
- peptic ulcer disease
- lung metastasis
- hypertension
role in cell
- replication in
- expression in
- phosphorylation in
- cell viability
- binding in
- migration
- activation in
- number
- chemotaxis
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- Wnt receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- protein phosphorylation
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- G-protein coupled receptor kinase activity
- beta-adrenergic receptor kinase activity