Prss12 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within zymogen activation. Predicted to be located in several cellular components, including axon; cytoplasmic vesicle; and synapse. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prss12 |
| Official Name | serine protease 12 [Source:RGD Symbol;Acc:69238] |
| Ensembl ID | ENSRNOG00000015353 |
| Bio databases IDs | |
| Aliases | serine protease 12 |
| Synonyms | BSSP-3, motopsin, MRT1, NEUROTRYPSIN, Nt, serine protease 12, serine protease 12 neurotrypsin (motopsin) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prss12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- KR
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Prss12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- autosomal recessive mental retardation type 1
- nonsyndromic mental retardation
- insomnia
- sarcopenia
- congenital heart disease
regulates
role in cell
- quantity
- function
- exocytosis by
- thickness
- branching
- centralization in
- grouping
- centralization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- presynaptic regions
- Plasma Membrane
- synapse
- cytoplasmic vesicles
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prss12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- exocytosis
Cellular Component
Where in the cell the gene product is active
- dendrite
- synaptic cleft
- terminal button
- cytoplasmic vesicle
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type peptidase activity
- serine-type endopeptidase activity