Prss12

Enables serine-type endopeptidase activity. Involved in exocytosis. Acts upstream of or within zymogen activation. Located in several cellular components, including dendrite; synaptic cleft; and terminal bouton. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prss12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Prss12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Prss12 gene, providing context for its role in the cell.