Dclre1c Gene Summary [Rat]
Predicted to enable 5'-3' DNA exonuclease activity; damaged DNA binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and telomere maintenance. Predicted to act upstream of or within several processes, including B cell differentiation; DNA metabolic process; and response to ionizing radiation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of nonhomologous end joining complex. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dclre1c |
| Official Name | DNA cross-link repair 1C [Source:RGD Symbol;Acc:708574] |
| Ensembl ID | ENSRNOG00000015980 |
| Bio databases IDs | |
| Aliases | DNA cross-link repair 1C |
| Synonyms | 9930121L06Rik, Art, Artemis, A-SCID, DCLREC1C, DNA cross-link repair 1C, RS-SCID, SCIDA, SNM1C, SNM1L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dclre1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-lactamase superfamily domain
- endonuclease
- 5'-3' exonuclease
- DNA repair metallo-beta-lactamase
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
- single-stranded DNA specific endodeoxyribonuclease
Pathways
Biological processes and signaling networks where the Dclre1c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Omenn syndrome
- Athabascan severe combined immunodeficiency
- cancer
- severe combined immunodeficiency
- Susac syndrome
- postmenopausal osteoporosis
- chromosomal instability
- partial severe combined immunodeficiency
- B-cell non-Hodgkin disease
- Aicardi-Goutieres syndrome 1
role in cell
- proliferation
- cell viability
- growth
- formation in
- survival
- differentiation
- molecular cleavage in
- formation
- number
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dclre1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- V(D)J recombination
- B cell differentiation
- adaptive immune response
- telomere maintenance
- double-strand break repair via nonhomologous end joining
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nonhomologous end joining complex
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- protein binding
- endonuclease activity
- 5'-3' exodeoxyribonuclease activity
- damaged DNA binding
- single-stranded DNA specific endodeoxyribonuclease activity