Galnt1 Gene Summary [Rat]
Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galnt1 |
| Official Name | polypeptide N-acetylgalactosaminyltransferase 1 [Source:RGD Symbol;Acc:620358] |
| Ensembl ID | ENSRNOG00000016207 |
| Bio databases IDs | |
| Aliases | polypeptide N-acetylgalactosaminyltransferase 1 |
| Synonyms | GALNAC-T1, polypeptide N-acetylgalactosaminyltransferase 1, pp-Galnac-T1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Galnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- Glycosyl transferase family 2
- Ricin-type beta-trefoil
- cytoplasmic domain
- polypeptide N-acetylgalactosaminyltransferase
- enzyme
- manganese ion binding
- Glycosyltransferase like family 2
- ricin B-type lectin domain, beta-trefoil fold
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- hypoplasia
- hypoalbuminemia
- systemic juvenile idiopathic arthritis
- hyperplasia
- stenosis
- aortic regurgitation
- bladder neoplasia
role in cell
- cell rolling
- activation in
- adhesion
- number
- proliferation
- morphology
- accumulation in
- transmigration
- distribution in
- O-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Galnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein O-linked glycosylation
- protein O-linked glycosylation via serine
- protein O-linked glycosylation via threonine
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- Golgi cisterna membrane
- membrane
- Golgi apparatus
- Golgi membrane
- extracellular region
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- manganese ion binding
- carbohydrate binding
- polypeptide N-acetylgalactosaminyltransferase activity