Btc Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including positive regulation of fibroblast proliferation; positive regulation of mitotic nuclear division; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of otitis media. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btc |
| Official Name | betacellulin [Source:RGD Symbol;Acc:620275] |
| Ensembl ID | ENSRNOG00000002728 |
| Bio databases IDs | |
| Aliases | betacellulin |
| Synonyms | Bcn, betacellulin, betacellulin, epidermal growth factor family member |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Btc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor protein tyrosine kinase activator
- epidermal growth factor receptor binding
- ectodomain
- receptor agonist activity
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Btc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- diabetes mellitus
- rheumatoid arthritis
- chronic obstructive pulmonary disease
- cardiac fibrosis
- diverticular disease
- arthritis
- hyperglycemia
- androgenic alopecia
- nephrosis
role in cell
- proliferation
- activation in
- phosphorylation in
- degradation in
- apoptosis
- internalization by
- differentiation
- survival
- cell death
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endocytic vesicle membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Btc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- ERBB4-ERBB4 signaling pathway
- positive regulation of cell division
- ERBB2-EGFR signaling pathway
- positive regulation of fibroblast proliferation
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- positive regulation of cell differentiation
- positive regulation of mitosis
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- extracellular space
- clathrin-coated endocytic vesicle membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- transmembrane receptor protein tyrosine kinase activator activity
- epidermal growth factor receptor binding
- receptor agonist activity