Atg10 Gene Summary [Rat]
Predicted to enable Atg12 conjugating enzyme activity. Predicted to be involved in ER overload response; macroautophagy; and protein modification by small protein conjugation. Predicted to act upstream of or within positive regulation of protein modification process and protein lipidation. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg10 |
| Official Name | autophagy related 10 [Source:RGD Symbol;Acc:1587624] |
| Ensembl ID | ENSRNOG00000016342 |
| Bio databases IDs | |
| Aliases | autophagy related 10 |
| Synonyms | 5330424L23Rik, 5430428K15Rik, Agp10, APG10, APG10L, Apg10p, Atg10l, autophagy related 10, LOC683259, mAPG10, PP12616 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atg10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-like protein transferase activity
- APG12 conjugating enzyme
- Autophagocytosis associated protein, active-site domain
- active site
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Atg10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- prostate cancer
- self-abusive behavior
role in cell
- senescence
- proliferation
- apoptosis
- autophagy in
- autophagy by
- assembly
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atg10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- protein transport
- protein lipidation
- mitochondrion degradation
- ER overload response
- positive regulation of protein modification process
- protein modification by small protein conjugation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- Atg12 ligase activity