ATG10 Gene Summary [Human]
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ATG10 |
| Official Name | autophagy related 10 [Source:HGNC Symbol;Acc:HGNC:20315] |
| Ensembl ID | ENSG00000152348 |
| Bio databases IDs | |
| Aliases | autophagy related 10 |
| Synonyms | 5330424L23Rik, 5430428K15Rik, Agp10, APG10, APG10L, Apg10p, Atg10l, autophagy related 10, LOC683259, mAPG10, PP12616 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATG10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-like protein transferase activity
- APG12 conjugating enzyme
- Autophagocytosis associated protein, active-site domain
- active site
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the ATG10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- prostate cancer
- self-abusive behavior
role in cell
- senescence
- proliferation
- apoptosis
- autophagy in
- autophagy by
- assembly
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATG10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- protein transport
- protein lipidation
- mitochondrion degradation
- ER overload response
- positive regulation of protein modification process
- protein modification by small protein conjugation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- Atg12 ligase activity