Snrpb Gene Summary [Rat]

Enables U1 snRNP binding activity and U2 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to act upstream of or within protein methylation. Part of U1 snRNP and U2 snRNP. Human ortholog(s) of this gene implicated in cerebrocostomandibular syndrome and mixed connective tissue disease. Orthologous to human SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Snrpb
Official Name
small nuclear ribonucleoprotein polypeptides B and B1 [Source:RGD Symbol;Acc:621301]
Ensembl ID
ENSRNOG00000006961
Bio databases IDs NCBI: 171365 Ensembl: ENSRNOG00000006961
Aliases small nuclear ribonucleoprotein polypeptides B and B1
Synonyms AL024368, CCMS, COD, D10Mgi26, SM11, small nuclear ribonucleoprotein B, small nuclear ribonucleoprotein polypeptides B and B1, SM-B, Sm-B/B', Smb'/b, SmB/SmB', SNRNP-B, SNRPB1
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snrpb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • proline glycine arginine motif
  • Sm and related proteins
  • proline glycine methionine motif
  • ribonucleoprotein binding
  • protein binding
  • glycine arginine rich domain
  • RNA binding

Pathways

Biological processes and signaling networks where the Snrpb gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • lymphoma
  • neoplasia
  • epithelial cancer
  • non-small cell lung cancer
  • liver cancer
  • lymphomagenesis
  • hepatocellular carcinoma
  • cerebrocostomandibular syndrome
  • organismal death
  • MELAS syndrome
regulated by
role in cell
  • survival
  • expression in
  • phosphorylation in
  • cell death
  • cell viability
  • apoptosis
  • growth
  • colony formation
  • G1 phase
  • splicing by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • catalytic step 2 spliceosome
  • Cytoplasm
  • cytosol
  • gems
  • spliceosomes
  • nucleoplasm
  • interchromatin granule clusters
  • Cajal bodies
  • cytoplasmic fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Snrpb gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • RNA splicing
  • protein methylation
  • nuclear mRNA splicing, via spliceosome
  • spliceosomal snRNP assembly

Cellular Component

Where in the cell the gene product is active
  • U5 snRNP
  • spliceosomal complex
  • U2-type spliceosomal complex
  • U7 snRNP
  • U2 snRNP
  • telomerase holoenzyme complex
  • U1 snRNP
  • U4 snRNP
  • nucleoplasm
  • U12-type spliceosomal complex
  • nucleus
  • catalytic step 2 spliceosome
  • cytoplasm
  • methylosome
  • SMN-Sm protein complex
  • U4/U6 x U5 tri-snRNP complex
  • histone pre-mRNA 3'end processing complex
  • U2-type catalytic step 2 spliceosome
  • cytosol
  • U2-type prespliceosome
  • U2-type precatalytic spliceosome
  • small nuclear ribonucleoprotein complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • telomeric RNA binding
  • snRNP binding
  • histone pre-mRNA DCP binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.