Tff3 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in response to peptide hormone. Predicted to be located in extracellular region and secretory granule. Predicted to be active in extracellular space. Biomarker of colon cancer and pre-malignant neoplasm. Orthologous to human TFF3 (trefoil factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tff3 |
| Official Name | trefoil factor 3 [Source:RGD Symbol;Acc:3847] |
| Ensembl ID | ENSRNOG00000001159 |
| Bio databases IDs | |
| Aliases | trefoil factor 3 |
| Synonyms | ITF, mITF, P1B, P1.b, TFI, TIFF3, trefoil factor 3, trefoil factor 3, intestinal |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tff3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Trefoil
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- gastric adenocarcinoma
- HER2 negative hormone receptor negative breast cancer
- epithelial thyroid cancer
- diabetes mellitus
- colon cancer
- nodular goiter
- primary ovarian cancer
- papillary thyroid cancer
- prostatic intraepithelial neoplasia
role in cell
- expression in
- activation in
- phosphorylation in
- apoptosis
- growth
- upregulation in
- number
- production in
- invasion by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- secretory granules
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tff3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of glucose metabolic process
- maintenance of gastrointestinal epithelium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding